Chie Nakajima Selected Research

7- (7- amino- 7- methyl- 5- azaspiro(2.4)heptan- 5- yl)- 6- fluoro- 1- (2- fluoro- 1- cyclopropyl)- 1,4- dihydro- 8- methoxy- 4- oxo- 3- quinolinecarboxylic acid

1/2019	Antibacterial Activity of DC-159a Against Salmonella Typhimurium.
9/2016	DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae.

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Chie Nakajima Research Topics

Disease

25	Tuberculosis (Tuberculoses) 01/2022 - 02/2007
11	Leprosy (Hansen's Disease) 12/2021 - 10/2008
11	Infections 12/2020 - 01/2012
6	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2022 - 11/2012
4	Neoplasms (Cancer) 02/2021 - 01/2014
3	Salmonella Infections (Salmonellosis) 01/2019 - 08/2015
2	Abscess 07/2022 - 07/2020
2	Hypoxia (Hypoxemia) 01/2022 - 01/2022
2	Communicable Diseases (Infectious Diseases) 12/2021 - 07/2017
2	Disease Progression 12/2020 - 01/2017
2	Pulmonary Tuberculosis 10/2019 - 12/2016
2	Melanoma (Melanoma, Malignant) 01/2017 - 01/2016
2	Persistent Infection 01/2017 - 07/2014
2	Campylobacter Infections (Campylobacter Infection) 10/2016 - 08/2015
1	Gram-Negative Bacterial Infections 01/2022
1	Extensively Drug-Resistant Tuberculosis 01/2021
1	Bacterial Infections (Bacterial Infection) 01/2019
1	Starvation 01/2019
1	Paratuberculosis (Johne's Disease) 01/2018
1	Sarcoma (Soft Tissue Sarcoma) 01/2017
1	AIDS-Related Complex (ARC) 01/2017
1	Latent Tuberculosis 12/2016
1	Leptospirosis 04/2016
1	Edema (Dropsy) 01/2016
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2016
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2016
1	Cattle Diseases (Bovine Diseases) 07/2014
1	Deltaretrovirus Infections (BLV Infection) 07/2013
1	Weight Loss (Weight Reduction) 01/2012

Drug/Important Bio-Agent (IBA)

15	Pharmaceutical PreparationsIBA 01/2022 - 02/2007
8	DNA (Deoxyribonucleic Acid)IBA 07/2022 - 10/2008
6	Ofloxacin (Ofloxacine)FDA LinkGeneric 12/2021 - 10/2008
6	QuinolonesIBA 12/2019 - 02/2011
5	Proteins (Proteins, Gene)FDA Link 09/2021 - 01/2014
5	LigandsIBA 02/2021 - 01/2014
5	FluoroquinolonesIBA 12/2019 - 01/2012
5	AntibodiesIBA 01/2018 - 01/2016
4	Streptomycin (Streptomycin Sulfate)FDA Link 09/2021 - 02/2007
4	16S Ribosomal RNAIBA 12/2020 - 07/2012
4	OsteopontinIBA 12/2016 - 01/2012
3	Antitubercular AgentsIBA 01/2022 - 01/2020
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 09/2016
3	AntigensIBA 01/2017 - 01/2014
3	sitafloxacinIBA 10/2016 - 01/2012
2	CopperIBA 01/2022 - 01/2022
2	Ethambutol (Myambutol)FDA LinkGeneric 01/2022 - 01/2020
2	Isoniazid (Ftivazide)FDA LinkGeneric 05/2021 - 01/2020
2	Monoclonal AntibodiesIBA 02/2021 - 01/2017
2	MethyltransferasesIBA 12/2020 - 01/2018
2	WQ-3810IBA 01/2020 - 12/2019
2	DNA GyraseIBA 12/2019 - 01/2019
2	7- (7- amino- 7- methyl- 5- azaspiro(2.4)heptan- 5- yl)- 6- fluoro- 1- (2- fluoro- 1- cyclopropyl)- 1,4- dihydro- 8- methoxy- 4- oxo- 3- quinolinecarboxylic acidIBA 01/2019 - 09/2016
2	Pyrazinamide FDA LinkGeneric 01/2018 - 05/2010
2	EnzymesIBA 12/2016 - 04/2016
2	ImmunosorbentsIBA 12/2016 - 04/2016
2	Rifampin (Rifampicin)FDA LinkGeneric 11/2010 - 10/2008
2	Nucleic AcidsIBA 07/2010 - 04/2008
1	Thymidylate SynthaseIBA 01/2022
1	4,6-dinitro-o-cresol (DNOC)IBA 01/2022
1	Tigecycline (Tygacil)FDA Link 01/2022
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2022
1	AntitoxinsIBA 09/2021
1	Colistin (Coly-Mycin)FDA Link 12/2020
1	Amikacin (A.M.K)FDA LinkGeneric 12/2020
1	ribosomal protein S12IBA 12/2020
1	8-methylguanosineIBA 12/2020
1	AgarIBA 07/2020
1	Cefoperazone (Cefoperazone Sodium)FDA Link 07/2020
1	Deoxycholic Acid (Sodium Deoxycholate)IBA 07/2020
1	Charcoal (Charbon)IBA 07/2020
1	Zinc Acetate FDA Link 01/2019
1	tosufloxacinIBA 01/2019
1	Tuberculin (PPD)IBA 01/2018
1	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 01/2018
1	Interferon-gamma (Interferon, gamma)IBA 01/2018
1	Dinoprostone (PGE2)FDA Link 01/2018
1	AluminumIBA 06/2017
1	Immune Checkpoint ProteinsIBA 01/2017
1	Immunoglobulin G (IgG)IBA 01/2017
1	Mycobacterium tuberculosis antigensIBA 01/2017
1	Blocking AntibodiesIBA 01/2017
1	lipoarabinomannan (LAM)IBA 01/2017
1	CytokinesIBA 12/2016
1	Ciprofloxacin (Cipro)FDA LinkGeneric 10/2016
1	Immune Checkpoint InhibitorsIBA 01/2016
1	Biological ProductsIBA 12/2014
1	B7-H1 AntigenIBA 01/2014
1	InterferonsIBA 01/2014
1	Membrane Proteins (Integral Membrane Proteins)IBA 07/2013
1	SuspensionsIBA 01/2013
1	Niacin (Nicotinic Acid)FDA LinkGeneric 07/2012
1	4-nitrobenzoic acidIBA 07/2012
1	CatalaseIBA 07/2012
1	Nitrate ReductaseIBA 07/2012
1	Interleukin-2 Receptors (IL 2 Receptor)IBA 01/2012
1	Recombinant DNA (Recombinant DNA Research)IBA 08/2011

Therapy/Procedure

4	Immunotherapy 02/2021 - 01/2016
4	Therapeutics 01/2019 - 07/2013
1	Drug Therapy (Chemotherapy) 01/2020
1	Oral Administration 01/2012